FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg).
It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells.
Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases.
The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG).
Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 49.1 kDa.
The protein migrates as 51-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human FoxP3 Protein, His Tag (FO3-H5243) is expressed from E. coli cells. It contains AA Met 1 - Pro 431 (Accession # Q9BZS1-1).
