MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily.
MICA contains one Ig-like C1-type (immunoglobulin-like) domain.
Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin.
MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells.
MICA is ligand for the KLRK1/NKG2D receptor.
MICA bind to KLRK1 leads to cell lysis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 61.0 kDa.
The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human MICA Protein, Fc,Avitag (MIA-H82F6) is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Gln 308 (Accession # Q29983-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Glu 24 - Gln 308
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q29983-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
