Integrin alpha-5/beta-1 is a receptor for ibrinogen.
Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin.
Integrin alpha-4/beta-1 is a receptor for VCAM1.
It recognizes the sequence Q-I-D-S in VCAM1.
Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.
It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
Integrin alpha-V/beta-1 is also a receptor for vitronectin.
Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).
When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.
特徴
Cynomolgus Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 113 kDa (ITGAV) and 83.6 kDa (ITGB1).
The protein migrates as 80-100 kDa and 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free (IT1-C52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 993 & Gln 161 - Asp 868 (Accession # A0A2K5WCD3-1 & A0A7N9D0D7).
