The Human Epidermal Growth Factor Receptor 2 (HER2) and HER3 form a potent pro-oncogenic heterocomplex upon binding of growth factor neuregulin-1β (NRG1β).
The HER2/HER3 extracellular dimer dynamics likely have important implications for modulating receptor activity.
特徴
Human Her2 & ErbB3 Protein, Fc Tag&Fc Tag, produced by co-expression of HER2 and ErbB3, has a calculated MW of 95.9 kDa & 94.9 kDa.
The protein migrates as 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Her2 & ErbB3 Protein, Fc Tag&Fc Tag (HE2-H5254) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 & Ser 20 - Thr 643 (Accession # P04626 & P21860).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc | C-Fc
Exp Region：Thr 23 - Thr 652 & Ser 20 - Thr 643
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P04626 | P21860
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
