PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes.
Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle.
Also expressed in erythroleukemia cells.
Inactive tyrosine kinase involved in Wnt signaling pathway.
Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway.
Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis.
Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 102.8 kDa.
The protein migrates as 125-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human PTK7 protein, Fc,Avitag (PT7-H82F5) is expressed from human 293 cells (HEK293). It contains AA Ala 31 - Thr 704 (Accession # Q13308-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Ala 31 - Thr 704
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q13308-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
