83-3887-70　Human ProS1 Protein, His Tag 1mg　PR1-H52H3-1mg

特徴

• 背景
• This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4.
• The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
• The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response.
• It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
• Multiple transcript variants encoding different isoforms have been found for this gene.
• [provided by RefSeq, Jul 2008]
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 45.6 kDa.
• The protein migrates as 53-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.