The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence.
KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells.
Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 41.3 kDa.
The protein migrates as 43-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus KLRG1 Protein, Fc Tag (KL1-C5269) is expressed from human 293 cells (HEK293). It contains AA Leu 60 - Pro 189 (Accession # A0A2K5WAP9).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：N-Fc
Exp Region：Leu 60 - Pro 189
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：A0A2K5WAP9
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Argine, 150 mM NaCl, pH7.5
