Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH).
A rate limiting step in cellular GSH synthesis is the availability of cysteine.
However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell.
System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate.
To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.
特徴
This protein .
仕様
容量：20ug
Source：Human SLC7A11&SLC3A2 Full Length Heterodimer Protein (VLP) (SLS-H52P4) is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2) (Accession # Q9UPY5 (SLC7A11) & P08195 (SLC3A2)).
Species Reactivity：Human
Host：HEK293
Exp Region：Val 2 - Leu 501 (SLC7A11) & Glu 2- Ala 630 (SLC3A2)
