This gene encodes a member of the class II cytokine receptor family.
The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor.
The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Isoform 1 may play a role in establishing and maintaining successful pregnancy.Isoform 2 is a receptor for IL22.
Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro).
May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 51 kDa.
The protein migrates as 65-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human IL-22BP Protein, Fc Tag (ILP-H5254) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Pro 231 (Accession # Q969J5-2).
