This gene encodes a member of the alkaline phosphatase family of proteins.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).
The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1.
The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.
Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme.
This enzyme may play a role in bone mineralization.
Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.3 kDa.
The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human ALPL Protein, His Tag (ALL-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ser 502 (Accession # P05186-1).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His
Exp Region：Leu 18 - Ser 502
Format：Liquid
Conjugate：Unconjugated
Swiss-Prot：P05186-1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：20 mM Tris, 150 mM NaCl, 20% Glycerol, pH7.5
