50% of cancers carry a TP53 mutation while many others affect other pathway components.
High-copy numbers of WT p53 peptide-MHC class I complexes were detected on tumor cells as compared to low copies on normal cells.
The Human HLA-A*0201 p53 (HMTEVVRRC) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and HMTEVVRRC peptide of the p53.
特徴
Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein is produced by co-expression of HLA and B2M loaded with p53 peptide.This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).The protein has a calculated MW of 36.3 kDa and 11.7 kDa.
The protein migrates as 38-43 kDa and 12 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human HLA-A*02:01&B2M&p53 (HMTEVVRRC) Complex Protein (HLP-H82E4) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & HMTEVVRRC).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His & C-Avi
Exp Region：Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & HMTEVVRRC peptide
