Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses.
Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized.
There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B).
CD32 is a low affinity receptor for IgG.
The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells.
CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIMbearing receptors may also be coexpressed and coengaged by specific ligands.
CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production.
The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
特徴
This protein carries a twin strep tag at the C-terminus.
The protein has a calculated MW of 23.7 kDa.
The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：500ug
Source：Human CD32a Protein, Strep Tag (CDA-H5284) is expressed from human 293 cells (HEK293). It contains AA Ala 36 - Ile 218 (Accession # P12318-1 (H167)).
