The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes.
The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface.
This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis.
Alternatively spliced transcript variants have been observed for this gene.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.5 kDa.
The protein migrates as 26-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human TNF-beta Protein, His Tag (TNB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 35 - Leu 205 (Accession # P01374).
