Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.
FSH is synthesized and secreted by the gonadotropic cells of the anterior pituitary gland and regulates the development, growth, pubertal maturation, and reproductive processes of the body.
FSH and luteinizing hormone (LH) work together in the reproductive system.FSH is a 35.5 kDa glycoprotein heterodimer, consisting of two polypeptide units, alpha and beta.
Its structure is similar to those of luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG).
The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids, while the beta subunits vary.
Both subunits are required for biological activity.
FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 25.5 kDa.
The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Human FSH alpha & beta Heterodimer Protein, His Tag (FSA-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Ser 116 (FSH alpha) & Asn 19 - Glu 129 (FSH beta) (Accession # P01215 (FSH alpha) & P01225 (FSH beta)).
