The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12.
IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway.
Promotes the proliferation of T-cells as well as NK cells.
Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas， IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 70.0 kDa.
The protein migrates as 85-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human IL-12 R beta 2, His Tag (ILB-H52H6) is expressed from human 293 cells (HEK293). It contains AA Lys 24 - Asn 622 (Accession # Q99665-1).
