The p75 neurotrophin receptor (p75NTR) was originally identified as a low-affinity receptor for neurotrophins(NGF R).p75NTR is a neurotrophic factor receptor.
Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4.
All neurotrophins bind to p75NTR.
This also includes the immature pro-neurotrophin forms.
Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections.
p75NTR is involved in pathways that promote neuronal survival and neuronal death.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 50.0 kDa.
The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human NGFR Protein, Fc Tag (NGR-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 29 - Asn 250 (Accession # P08138-1).
