IL1R1 also know as Interleukin-1 receptor type 1, is the receptor for IL1A, IL1B and IL1RN.
After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.
Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.
Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 63.1 kDa.
The protein migrates as 75-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human IL-1 RI Protein, Fc Tag (ILI-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Lys 336 (Accession # P14778).
