This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.2 kDa.
The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human GLP1R Protein, Fc Tag (GLR-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Glu 139 (Accession # P43220-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ala 21 - Glu 139
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P43220-1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50mMTris 100 mM Glycine,25 mM Argine,150 mM NaCl, pH7.5
