Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated.
The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction.
The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth.
The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas.
Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.2 kDa.
The protein migrates as 22-23 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
仕様
容量：500ug
Source：Human Pleiotrophin Protein, His Tag, premium grade (PLN-H5244) is expressed from E. coli cells. It contains AA Gly 33 - Asp 168 (Accession # P21246).
