MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues.
It has been shown to promote the survival, growth and function of dopamine-specific neurons.
MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures.
MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease.
Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.0 kDa.
The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human MANF Protein, His Tag (MAF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Leu 182 (Accession # P55145).
