83-3882-06　Biotinylated Human HLA-A*02：01＆B2M＆HBV （FLLTRILTI） Complex Protein （Monomer, MALS verified） 25ug　HLT-H82E9-25ug

特徴

• 背景
• Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV).
• The hepatitis B virus attacks the liver and can cause both acute and chronic diseases that put people at high risk of death from cirrhosis and liver cancer.
• The virus is most commonly transmitted from mother to child during birth and delivery, as well as through contact with blood or other body fluids.
• Hepatitis B virus (HBV) is a member of the hepadnaviral family.
• The virus particle (virion) consists of an outer lipid envelope and an icosahedral nucleocapsid core composed of the core protein.
• The nucleocapsid encloses the viral DNA and a DNA polymerase that has reverse transcriptase activity.
• The outer envelope contains embedded proteins that are involved in viral binding of, and entry into, susceptible cells.
• The surface antigens (HBsAg) decorating the lipid envelope of HBV are produced in excess during the life cycle of the virus, and its presence in blood indicates current hepatitis B infection.
• The Human HLA-A*0201 HBV ( FLLTRILTI) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and FLLTRILTI peptide of the HBV.
• 特徴
• Biotinylated Human HLA-A*02:01&B2M&HBV (FLLTRILTI) Complex Protein is produced by co-expression of HLA and B2M loaded with HBV peptide.This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).The protein has a calculated MW of 36.3 kDa and 11.7 kDa.
• The protein migrates as 40-42 kDa and 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.