CDNF is a member of the ARMET family and acts as a trophic factor for dopamine neurons.
CDNF inhibits the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.
When CDNF controlled after 6-OHDA-lesioning, it reestablishes the dopaminergic function and inhibits the degeneration of dopaminergic neurons in substantia nigra.
CDNF is universally expressed in neuronal and non-neuronal tissues.
The highest levels in the brain are found in the optic nerve and corpus callosum.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.4 kDa.
The protein migrates as 21-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Mouse CDNF, His Tag (CDF-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Leu 187 (Accession # Q8CC36).
