CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.
Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.
Hydrolyzes ATP and ADP equally well.
NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway.
CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 52.1 kDa.
The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CD39 (Q96A, N99A, E143A, R147E) Protein, His Tag (CD9-H52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 38 - Val 478 (Accession # P49961-1 (Q96A, N99A, E143A, R147E)).
