83-3881-22　Human ComplementC3a Protein, His Tag 50ug　COA-H5143-50ug

特徴

• 背景
• C3 is the major complement component serum.
• It is mainly synthesized by macrophages and liver.
• C3 plays a central role in the activation of the complement system.
• Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways.
• It is cleaved into two fragments, C3a and C3b.
• C3a anaphylatoxin is a mediator of local inflammatory process.
• In chronic inflammation, acts as a chemoattractant for neutrophils.
• After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
• It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 22.5 kDa.
• The protein migrates as 12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).