Glia Maturation Factor-Beta (GMF-Beta) is a 17 kDa protein nerve gorwth factor identified as a growth and differentiation factor in the vertebrate brain.Glia Maturation Factor-Beta stimulates differentiation of normal neurons as well as glial cells.
GMFB inhibits the proliferation of the N-18 neuroblastoma line and the C6 glioma line while promoting their phenotypic expression.GMF-beta inhances the phenotypic expression of glia & neurons thus inhibits the proliferation of their respective tumors when added to cell culture.
Although astrocytes produce GMF-b and stores it inside the cells, they don’t secrete the GMF-B into the cultured medium.
Cell- surface GMFb acts on the target cells at close range when cells are in direct contact.
GMF-Beta is produced by thymic epithelial cells and plays an important role in T cell development in favor of CD4+ T cells.GMF-Beta is a brain-specific protein which belongs to the actin-binding proteins (ADF) family.
GMF-beta appears to play a role in the differentiation, maintenance, and regeneration of the nervous system.
It also supports the progression of certain auto-immune diseases, possibly through its ability to induce the production and secretion of various pro-inflammatory cytokines.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 18.6 kDa.
The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：20ug
Source：Human GMF-beta, His Tag (GMA-H5145) is expressed from E. coli cells. It contains AA Ser 2 - His 142 (Accession # P60983).
