Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family.
Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin.
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Mesothelin / MSLN can interacts with MUC16.
The membrane-anchored forms of MSLN may play a role in cellular adhesion.
MPF potentiates megakaryocyte colony formation in vitro.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 49.6 kDa.
The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Mesothelin (391-598), Fc Tag (MSN-H5267) is expressed from human 293 cells (HEK293). It contains AA Ser 391 - Ser 598 (Accession # AAH09272.1).
Species Reactivity：Human
Host：HEK293
Tag：N-Fc
Exp Region：Ser 391 - Ser 598
Format：Powder
Conjugate：Unconjugated
Endotoxin：0.2 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
