Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family.
TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer.
Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer.
Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
特徴
This protein carries an Avi tag (Avitag) at the N-terminus, followed by a human IgG1 Fc tag.
The protein has a calculated MW of 75.7 kDa.
The protein migrates as ＞145 kDa under reducing (R) condition, and 135-235 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human OX40 Ligand Protein, Avitag,Fc Tag, premium grade (OXL-H82F5) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # P23510-1).
Species Reactivity：Human
Host：HEK293
Tag：N-Avi & N-Fc
Exp Region：Gln 51 - Leu 183
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：P23510-1
Endotoxin：0.01 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, PH7.5
