83-3880-41　Human CD38＆Serum Albumin Protein, His Tag （MALS verified） 100ug　CDS-H52H7-100ug

特徴

• 背景
• CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.
• CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
• CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
• These reaction products are essential for the regulation of intracellular Ca2+.
• The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
• The CD38 protein is a marker of cell activation.
• It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism.
• CD38 has been used as a prognostic marker in leukemia.serum albumin (SA) is also known as ALB, which is the main protein of plasma and has a good binding capacity for water,Ca2+,Na+,K+,fatty acids,hormones, bilirubin and drugs.The main function of SA is the regulation of the colloidal osmotic pressure of blood.
• As Major zinc transporter in plasma, SA typically binds about 80% of all plasma zinc.
• A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood.
• Defects in serum albumin can cause familial dysalbuminemic hyperthyroxinemia which is a form of euthyroid hyperthyroxinemia that is due to increased affinity of serum albumin for T4.
• It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 98.7 kDa.
• The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.