83-3879-67　Human CXCL1 Protein, Fc Tag （MALS verified） 1mg　CX1-H5253-1mg

特徴

• 背景
• Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small molecule of cytokines belonging to the CXC chemokine family.
• Also known as growth-regulated oncogene alpha (Growth-regulated oncogene alpha, GROα).
• It's also known as keratinocytes-derived chemokine (KC) in mice or cytokine-induced neutrophil chemoattractant type-1 (CINC-1) in rats.
• In humans, this protein is encoded by the gene Cxcl1 and is located on human chromosome 4 among genes for other CXC chemokines.
• The chemokine CXCL1 is expressed by macrophages, neutrophils and epithelial cells.
• The chemokine CXCL1 has a chemotactic effect on neutrophils.
• CXCL1 binds to the chemokine receptor CXCR2 and plays a role in cell chemotaxis.
• Human CXCL1 is clustered on chromosome 4 adjacent to many CXC chemokine genes.
• Major roles of CXCL1 include neovascularization, inflammation, wound healing, and tumorigenesis
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 34.3 kDa.
• The protein migrates as 37-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.