Matrix metalloproteinase 3 (MMP-3), also known as stromelysin 1 and progelatinase, is encoded by the MMP3 gene.
The expression of MMP3 is mainly regulated at the transcriptional level, where gene promoters respond to a variety of stimuli including growth factors, cytokines, carcinogens and proto-oncogene products.
MMP-3 degrade II, III, IV, IX and X collagen, proteoglycan, fibronectin, laminin, and elastin.
In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7 and MMP-9, so MMP-3 plays a key role in connective tissue remodeling.
This enzyme is involved in wound repair, atherosclerotic progression, and tumor initiation.
Studies of MMP-3 wild type and gene knockout in mice have shown that MMP-3 increases the permeability of the blood-brain barrier after traumatic injury.
Nuclear MMP-3 works as a transcription factor and protease.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 30.7 kDa.
The protein migrates as 32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human MMP-3, His Tag (MM3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 18 - Thr 272 (Accession # P08254-1).
