T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3.
CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.
CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction.
CD4 induces the aggregation of lipid rafts.
CD4 is a primary receptor used by HIV-1 to gain entry into host T cells.
HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.
Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 44.0 kDa.
The protein migrates as 52-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Rhesus macaque CD4,His,Avitag (CD4-R82E3) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Trp 390 (Accession # G7N5T8-1).
