Neuronal Pentraxin 2 (NPTX2), also named neuronal activity-regulated pentraxin, is a secreted glycoprotein characterized by a cyclic multimeric structure.
In vivo, NTPX2 exerts various neurological effects by combining with the transmembrane protein neuronal pen traxin receptor (NPTXR).
NPTX2 was thought to play a vital role in transmitting neurotrans mitters and maintaining synaptic plasticity.
It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.
Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.7 kDa.
The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human NPTX2, His Tag (NP2-H52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 16 - Leu 431 (Accession # P47972).
