Neurogranin is as a small protein encoded by the NRGN gene.
it is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway. Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium. Phosphorylation by protein kinase C lowers its binding ability.
It is a potential biomarker of neurological and mental diseases.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 9.5 kDa.
The protein migrates as 15 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human Neurogranin, His Tag (NEN-H5144) is expressed from E. coli cells. It contains AA Met 1 - Asp 78 (Accession # Q92686).
