Interleukin-24 (IL-24, also known as melanoma differentiation-associated gene-7) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -22, -24 and -26.
Interleukin 24 signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2.
Upon binding to its receptors, IL-24 induces rapid activation of Stat-1 and Stat-3 transcription factors, which appear to play a role in cell survival and proliferation .
Structurally and functionally, IL-24 is highly conserved across species.IL-24 has been shown to possess cancer-specific apoptosis-inducing activity, and has therefore been suggested as a potential anti-cancer agent.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.0 kDa.
The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IL-24 Protein, His Tag (IL4-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 52 - Leu 206 (Accession # Q13007-1).
