LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs.
LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 61.7 kDa.
The protein migrates as 66-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus LGR5, His Tag (LG5-C52H7) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Gly 557 (Accession # G7PI19-1).
