Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily.
This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3.
The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 59.5 kDa.
The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IL-3 R alpha Protein, Fc Tag (ILA-H5252) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305 (Accession # P26951-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Thr 19 - Arg 305
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P26951-1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
