Among its related pathways are RET signaling and HIV Life Cycle.
GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding.
An important paralog of this gene is KL.
Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear.
We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues.
Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells.
Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 110.5 kDa.
The protein migrates as 130-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Rat Klotho beta, His Tag (KLB-R52H6) is expressed from human 293 cells (HEK293). It contains AA Phe 53 - Pro 994 (Accession # D3Z8T6-1).
