Coagulation factor VII is also known as F7, SPCA and Proconvertin.
Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
Initiates the extrinsic pathway of blood coagulation.
Serine protease that circulates in the blood in a zymogen form.
Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis.
In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis.
Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 47.7 kDa.
The protein migrates as 57-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：20ug
Source：Mouse Coagulation factor VII, His Tag (COI-M52H1) is expressed from human 293 cells (HEK293). It contains AA Ala 42 - Leu 446 (Accession # P70375-1).
