Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production.
These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11.
The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis.
Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish.
Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 45.6 kDa.
The protein migrates as 53-57 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse IL-11 Protein, Fc Tag (IL1-M5243) is expressed from human 293 cells (HEK293). It contains AA Pro 22 - Leu 199 (Accession # P47873).
Species Reactivity：Mouse
Host：HEK293
Tag：N-Fc
Exp Region：Pro 22 - Leu 199
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P47873
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：51 mM Tris,100 mM Glycine,25 mM Arginine,150 mM NaCl,pH7.5
