Sclerostin (SOST) is also known as Sclerosteosis, VBCH, is a secreted glycoprotein with a signal peptide for secretion and a C-terminal cysteine knot-like (CTCK) domain and belongs to the Cerberus/DAN family of bone morphogenetic protein (BMP) antagonists.
Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation.
More recently Sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signalling pathway.
Wnt pathway inhibition under these circumstances is antagonistic to bone formation (meaning Sclerostin antagonizes bone formation).
It has been shown that SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity.
Sclerostin production by osteocytes is inhibited by parathyroid hormone, mechanical loading and cytokines including oncostatin M, cardiotrophin-1 and leukemia inhibitory factor.
Sclerostin production is increased by calcitonin.
Thus, osteoblast activity is self regulated by a negative feedback system.
Mutations of Sclerostin is associated with the syndrome Sclerosteosis, and reduced sclerostin expression results in a milder form of the disorder called van Buchem disease.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 23.4 kDa.
The protein migrates as 31-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus SOST, His Tag (SOT-C5246) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Tyr 213 (Accession # G7PUY1-1 (D181H)).
