Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family.
CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
LILRB4 / CD85K is receptor for class I MHC antigens.
CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance.
LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 53.3 kDa.
The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human LILRB4, Mouse IgG2a Fc Tag (LI4-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # AAH26309.1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Gln 22 - Glu 259
Format：Powder
Conjugate：Unconjugated
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
