Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family.
Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.
CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells.
In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 26.7 kDa.
The protein migrates as 37-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Rat Siglec-3, His Tag (CD3-R52H4) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - Gln 240 (Accession # F1LTZ3-1).
