Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V.
Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin.
It recognizes the sequence R-G-D in its ligands.
Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1.
Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes.
This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
特徴
Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 80.1 kDa (ITGB6).
Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus.
仕様
容量：100ug
Source：Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free (IT6-R52E6) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Gly 22 - Pro 708 (ITGB6) (Accession # NP_001385621.1 (ITGAM) & Q6AYF4 (ITGB6)).
Species Reactivity：Rat
Host：HEK293
Tag：C-10×His | Native
Exp Region：Phe 31 - Pro 988 (ITGAM) & Gly 22 - Pro 708 (ITGB6)
