Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium.
Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha.
An inhibitor of both down regulates tumor angiogenesis.
During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
特徴
Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 81.6 kDa (ITGB3).
Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus.
仕様
容量：1mg
Source：Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free (IT5-R52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5) (Accession # NP_001385621.1 (ITGAM) & NP_671480.2 (ITGB5)).
Species Reactivity：Rat
Host：HEK293
Tag：C-10×His | Native
Exp Region：Phe 31 - Pro 988 (ITGAM) & Leu 25 - Asn 719 (ITGB5)
