Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells.
Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton.
It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex.
High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta.
This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms.
Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
特徴
Rat ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free, has a calculated MW of 113 kDa (ITGAV) & 77 kDa (ITGB8).
Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB8 contains no tag but a basic tail at the C-terminus.
仕様
容量：1mg
Source：Rat Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer, His Tag&Tag Free (IT8-R52E1) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 & Gly 22 - Ser 679 (Accession # NP_001385621.1 & A0A0G2JVU1).
