Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.
It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD).
Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
特徴
This protein carries no "tag".
The protein has a calculated MW of 14.5 kDa.
The protein migrates as 15-16 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human Alpha-Synuclein, Tag Free (ALN-H5214) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1).
