Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.
It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD).
Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 16.4 kDa.
The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Mouse Alpha-Synuclein, His Tag (ALN-M52H6) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # O55042-1).
