Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens.
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component.
It probably recognizes the R-G-D peptide in C3b.
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1.
It recognizes P1 and P2 peptides of fibrinogen gamma chain.
In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
May regulate phagocytosis-induced apoptosis in extravasated neutrophils.
May play a role in mast cell development.
Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
特徴
Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free.
The protein has a calculated MW of 128 kDa | 80 kDa.
The protein migrates as 80-90 kda and 155-175 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free (IT2-C52E2) is expressed from human 293 cells (HEK293). It contains AA Phe 18 - Pro 1106 (ITGAM) & Gln 17 - Gln 695 (ITGB2) (Accession # A0A8C0M9J9-1 (ITGAM) & Q9TU04-1 (ITGB2)).
