Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses.
IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells.
IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains.
The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4.
IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation.
IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 14.2 kDa.
The protein migrates as 29-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Cynomolgus IL-13, His Tag (IL3-C5249) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Asn 132 (Accession # ABG75889.1).
