Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40).
IL-12 is involved in the differentiation of naive T cells into Th1 cells.
It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells.
It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ.
IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.
IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
特徴
This protein carries no "tag".
The protein has a calculated MW of 58.9 kDa.
The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：20ug
Source：Human IL-12 Protein, premium grade (IL2-H5210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 & Arg 23 - Ser 219 (Accession # P29460-1 & P29459-1).
